Bridges are built in a variety of locations, many of which are susceptible to multiple extreme hazards (earthquakes, vehicle collisions, tsunamis or storm surges, and blasts as a minimum for some locations). In addition, they must be built to achieve the objectives of both accelerated bridge construction (ABC) and rapid return to service following a disaster. Meeting some or all of these demands/objectives drives the development of innovative multi-hazard design concepts. This paper presents recent research on structural fuses and concrete-filled steel shapes strategies developed for this purpose. The structural fuse concept considered here for seismic resistance was developed and experimentally validated for implementation in a composite multi-column pier using double composite rectangular columns of Bi-Steel panels. Experimental results from another series of tests on the blast resistance of concrete-filled-steel-tubes support the blast resistance of the concept. In parallel, the development and design of a conceptual multi-hazard resistant steel plate shear wall box pier concept considered each of the four aforementioned hazards by use of simplified analyses for design, and of advanced nonlinear finite element analyses to confirm that the proposed steel plate shear wall box system provides adequate ductile performance and strength for each of the hazards.