Seismic risk in regions of low seismicity is evaluated using the UK as an example. This involves quantifying the seismic hazard and also the vulnerability functions for a range of typical structures. Predictions are made as to the effects of a range of specific earthquakes occurring under two existing areas of the UK. By integrating the hazard and vulnerability seismic risk has been calculated in terms of cost and fatalities and compared to those arising from other types of hazard. Recommendations are made as to when, and in what form, seismic considerations may be necessary.